[C9] PertReason: A Knowledge-Grounded Benchmark and Framework for Cell-State-Conditioned Mechanistic Reasoning of Perturbation Effects
Dongkwan Kim*, Yiming Gao*, Yining Yang, Yang Shen. Neural Information Processing Systems Evaluations & Datasets Track (NeurIPS E&D), 2026
One-sentence Summary: We introduce PertReason, comprising a benchmark that evaluates whether perturbation predictions are supported by cell-specific mechanisms and a framework that aligns predicted outcomes with biologically grounded explanations.
